Peptic
ulcer is defined as mucosal erosion equal to or greater than 0.5cm. It is the
commonest ulcer in the gastrointestinal tract. Although the pathogenesis of
peptic ulcer disease is not fully understood, three major causative factors are
recognized: 1) Infection with gram negative Helicobacter pylori, 2) increased
hydrochloric acid secretion and 3) inadequate mucosal defense against gastric
acid. Treatment approaches include:
- Eradicating the H. pylori infection
- Reducing secretion of gastric acid or neutralizing the acid after it is released, and/or
- Providing agents that protect the gastric mucosa from damage.
